Immunological changes of chronic oral exposure to depleted uranium in mice

A study assessing the genotoxicity in rats after chronic oral exposure to a low dose of depleted uranium.

PURPOSE The aim of this study was to evaluate the potential genotoxicity induced by chronic oral exposure to depleted uranium (DU). MATERIALS AND METHODS Weanling Wistar rats (F(0)), 50/sex/group, were exposed to DU in food at doses of 0, 4, or 40 mg kg(-1)day(-1) for four months. They were subsequently mated, resulting in the birth of F(1) rats. Fifty F(l) weanlings/sex/group were exposed fo...

[Depleted uranium: sources, exposure and health effects].

Novel Pharmacological Approaches for Treatment of Neurotoxicity Induced by Chronic Exposure to Depleted Uranium PRINCIPAL INVESTIGATOR:

DAMD 17 - 02 - 1 - 0212 TITLE : Neurotoxicity From Chronic Exposure to Depleted Uranium

s and Presentations Lasley, S.M. and Vietti, K.R. Acute exposure to uranium decreases potassium-stimulated hippocampal glutamate release. The Toxicologist 78, 1140, 2004. Lasley, S.M. and Vietti, K.R.N. Acute exposure to uranium in vitro decreases potassiumstimulated hippocampal glutamate release. Military Health Research Forum, San Juan, Puerto Rico, April 25-28, 2004. Lasley, S.M. and Vietti,...

A Review on Toxicodynamics of Depleted Uranium

Depleted uranium (DU) is an important by product in uranium enrichment process. Due toits applications in civilian and also military activity, DU emerged as environmental pollutant.The exposure to DU can occur via external or internal pathways. In external exposure, mainlybeta radiation from the decay products contributes to DU toxicity. Internal exposure to DUis more im...